Folic Acid and Vitamin B12 Increase Risk of Cancer in Patients with Heart Disease(11/19/2009) Researchers from Norway have reported that folic acid and B12 supplements in patients with ischemic heart disease increase the risk of cancer and all-cause mortality. The details of this study appeared in the November 18, 2009 issue of the Journal of the American Medical Society.
Early Morning Colonoscopies Detect More Polyps(11/13/2009) Researchers affiliated with the Veterans Administration of greater Los Angeles have reported that a greater number of polyps was detected among patients seen early in the morning than among patients seen later in the day. The reasons for this are uncertain, but it’s possible that the lower rate of polyp detection later in the day is the result of provider fatigue or less complete bowel preparation. These results were published in November, 2009 issue of Clinical Gastroenterology and Hepatology.
Israeli Jewish Holocaust Survivors May Have Increased Risk of Cancer(11/12/2009) Researchers from Israel have reported that the incidence of all cancers, and especially breast and colorectal cancers, is higher among Israeli Jews who were potentially exposed to the Holocaust compared with those who were not. The details of this study were published in the November 4, 2009 issue of the Journal of the National Cancer Institute.
Daily Aspirin May Decrease Risk of Colorectal Cancer in Lynch Syndrome(10/7/2009) Researchers involved in the international multi-institutional study, CAPP2, have reported that the use of daily aspirin may reduce the incidence of colorectal adenomas and cancers in individuals with hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch Syndrome. The details of this study were presented on September 21, 2009 at Europe’s largest cancer congress, ECCO 15-ESMO 34, in Berlin.
High Time Costs for Informal Care Givers of Cancer Patients(9/10/2009) Researchers from the National Cancer Institute (NCI) have reported that the time spent by informal caregivers is significant and an important component in the overall burden of cancer care. The details of this study appeared in the September 4, 2009 issue of Cancer.
Adherence Important for Effectiveness of Diet in Preventing Colorectal Adenoma Recurrences(8/31/2009) Researchers associated with the U.S. Polyp Prevention Trial have reported that high compliance with a low-fat, high-fiber diet is associated with a reduced risk of adenoma recurrence. The details of this study appeared in the September 1, 2009 issue of the American Journal of Epidemiology.
Regular Aspirin Use Decreases Mortality After the Diagnosis of Colorectal Cancer(8/14/2009) Researchers from Harvard Medical School have reported that regular aspirin use after the diagnosis of colorectal cancer decreases the risk or dying of colorectal cancer that expresses COX-2. The details of this study were published in the August 12, 2009 issue of the Journal of the American Medical Association.
No Benefit of Avastin® in Early-stage Colon Cancer(6/4/2009) Researchers involved in an international multicenter study have reported that addition of Avastin® (bevacizumab) to post-surgery chemotherapy does not improve disease-free survival among patients with early-stage colon cancer. The details of this Phase III clinical trial were presented at the 2009 annual meeting of the American Society of Clinical Oncology on May 31 in Orlando, Florida. These results were previously made available in a press release from Roche.
Adding Eloxatin® to Adjuvant 5-FU Leucovorin Improves Survival of Stage II-III Colon Cancer: Six-year Follow-up(5/21/2009) Researchers affiliated with Multicenter International Study in the Adjuvant Treatment of Colon Cancer (MOSAIC) study have reported that the addition of Eloxatin® (oxaliplatin) (FOLFOX4) to 5-FU leucovorin improves (LV5FU2) five-year disease-free survival from 67.4% to 73.3% in patients receiving 5-FU-leucovorin. The details of this study appeared in an early online publication in the Journal of Clinical Oncology on May 18, 2009.
Folic Acid May Be Beneficial in Patients with Recurrent Colorectal Adenoma Who Are Folate Deficient(11/20/2009) Researchers affiliated with the Health Professional Follow-Up Study and the Nurses’ Health Study have reported that folic acid supplementation in patients with recurrent colorectal adenoma was not protective or harmful in most patients. However, patients who were folate deficient had a significant 39% decrease in adenoma recurrence. The details of this study appeared in an early online publication on October 28, 2009 in the American Journal of Clinical Nutrition.
Vectibix® plus Chemotherapy Improves Progression-free Survival After Initial Treatment of Metastatic Colorectal Cancer(9/30/2009) Researchers involved in the international randomized trial, PRIME, have reported that the addition of Vectibix® (panitumumab) to FOLFOX4 chemotherapy improves progression-free survival (PFS) compared with FOLFOX4 alone in patients with previously untreated metastatic colorectal cancer. This benefit was only observed in patients whose tumors did not contain a mutation in the KRAS gene (those with wild type). These results were presented at the Joint ECCO 15 -34th ESMO Multidisciplinary Congress in Berlin, September 20-24, 2009.
Vectibix® Improves PFS in Second-line Therapy of Colorectal Cancer with FOLFIRI(9/23/2009) Researchers involved in an international randomized trial have reported that the addition of Vectibix® (panitumumab) to FOLFIRI (5-fluorourcil, Camptosar® [irinotecan], and leucovorin) improves progression-free survival (PFS) in patients with colorectal cancer with wild-type KRAS receiving second-line therapy. The details of this study were presented at the Joint ECCO 15-34th ESMO Congress in Berlin, September 20-24.
FDG-PET Scans Reduce Number of Futile Surgeries for Hepatic Colorectal Metastases(8/25/2009) Researchers from the Netherlands have reported that the use 18F-FDG PET scans reduced the number of futile surgeries for hepatic metastases from 45% to 28%. The details of this study appeared in the July 2009 issue of the Journal of Nuclear Medicine.
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