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Leukemia - Screening/Prevention
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Formaldehyde Exposure May Increase Risk of Blood and Lymphatic Cancers (6/25/2009)
Researchers from the National Cancer Institute have reported that industrial workers who are exposed to formaldehyde may be at an increased risk of dying from blood and lymphohematopoietic malignancies, particularly myeloid leukemia but also Hodgkin’s lymphoma and multiple myeloma, according to the results of a study published in the Journal of the National Cancer Institute.
Increasing Body Mass Associated with Increasing Cancer Incidence and Mortality (11/19/2007)
Researchers affiliated with the UK Million Women Study have reported that increasing body mass index (BMI) is associated with an increased risk of 10 specific types of cancer out of 17 evaluated. The details of this study appeared in an early on-line publication on November 6, 2007 in the British Medical Journal.
Increased Exposure to Infection Decreases Incidence of Childhood Acute Lymphoblastic Leukemia (6/1/2005)
Researchers affiliated with the United Kingdom Childhood Cancer Study (UKCCS) have reported that day care in infancy decreases the risk of childhood acute lymphoblastic leukemia (ALL).
Vitamin B12 Deficiency Occurs in Over 10% of Patients with Plasma Cell Dyscrasias (8/19/2004)
Researchers from the Cleveland Clinic have reported that 13.6% of patients with plasma cell dyscrasias have vitamin B12 deficiency. They suggest that “serum vitamin B12 measurements should be part of the initial evaluation and subsequent workups for anemia in patients with plasma cell dyscrasias.” The details of this report appeared in the August 2004 issue of Cancer.
Long-Term Outcomes from Childhood ALL Affected by Irradiation (8/14/2003)
Researchers from St. Jude Children’s Research Hospital have reported that children with ALL who have not received radiation to the brain have normal long-term survival while irradiation is associated with the development of second neoplasms, a slight excess in mortality, and an increased unemployment rate. These findings were published in the August 14, 2003 issue of the
New England Journal of Medicine.
Second Malignancies Are Frequent After Stem Cell Transplants (4/11/2003)
A study of second malignancies in children receiving stem cell transplants revealed that the risk of post-transplant malignancies, especially solid tumors, continues to increase even 20 years after transplant, necessitating long-term close follow-up for these patients. These results were reported by researchers from the University of Minnesota in the April 1, 2003 issue of the
Journal of Clinical Oncology.
Epoetin Improves Quality of Life of Cancer Patients (4/3/2003)
In the April 7, 2003 issue of the
British Journal of Cancer, French researchers present data on a randomized trial quantifying the improvement in quality of life measurements with epoetin compared to placebo. Recombinant erythropoietin (epoetin) is used to treat anemia in cancer patients. Procrit® is the usual form of epoetin, but more recently Aranesp®, a longer acting formulation, has been approved for use by the FDA. All clinicians recognize that anemia can produce significant morbidity, but there is controversy over how and when to use epoetin to correct anemia.
Thalidomide Regimen Effective For Myeloid Metaplasia with Myelofibrosis (3/20/2003)
Researchers from the Mayo Clinic reported in the April 1, 2003 issue of
Blood that lowering the dose of thalidomide in patients with myeloid metaplasia with myelofibrosis (MMM) and adding oral prednisone improved the therapeutic index of thalidomide. (3)
Adolescents with Acute Lymphoblastic Leukemia Have Better Survivals When Treated on Pediatric Rather Than Adult Protocols (3/3/2003)
Adolescents, ages 15 to 20, with acute lymphoblastic leukemia (ALL), are treated on either pediatric or adult protocols. The main difference between pediatric and adult protocols is dose intensity. As a generality, pediatric protocols for ALL involve higher doses of drugs administered over a shorter period of time. There have been few analyses of the impact of protocol choice on the outcome of adolescents with ALL. In the March 1, 2003 issue of the
Journal of Clinical Oncology, French researchers report that survival of adolescent patients with ALL was improved if they received treatment on pediatric protocols.
Exposure to Herbicides such as Agent Orange Linked to Chronic Lymphocytic Leukemia (1/29/2003)
Exposure of individuals to herbicides has been associated with an increased incidence of Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). There has been no clear link between exposure to herbicides and the development of acute or chronic leukemia. However, on January 23, 2003 the National Institute of Medicine, which is part of the National Academy of Sciences, released a report linking exposure of herbicides to an increased risk of developing chronic lymphocytic leukemia (CLL). One importance of these findings is that Veterans, who were exposed to the herbicide agent orange, can claim service connected disability if they develop HL, NHL or CLL.
Vitamin Supplementation Use During Pregnancy Decreases the Incidence of Neuroblastoma (8/28/2002)
It is generally recommended that pregnant women receive vitamin supplementation during pregnancy to assure normal growth and development of the fetus. Several studies have suggested that vitamin supplementation during pregnancy can prevent birth defects in the fetus. There have also been associations established between vitamin supplementation and the risk of acute lymphoblastic leukemia and brain tumors. In fact, it has been suggested that the widespread use of vitamin supplementation in pregnant women has led to a decrease in the incidence of childhood medulloblastoma. However, the role of vitamin supplementation during pregnancy in the prevention of neuroblastoma has not been extensively explored. Researchers for several institutions in the U.S. and Canada have reported in the September 2002 issue of the journal of
Epidemiology that vitamin supplementation during pregnancy may decrease the incidence of neuroblastoma.
Component of Red Wine Has Potential Anti-cancer Properties (5/20/2002)
According to results recently published in the
British Journal of Cancer, the cancer preventive agent resveratrol metabolizes into the anti-leukemic agent piceatannol, which may provide a novel explanation for the cancer preventive properties of resveratrol.
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