Stages II-III


Stage II or III multiple myeloma is characterized by an intermediate or high amount of cancer in the body. Patients with either of these stages of multiple myeloma often have bone complications as a result of their disease and usually experience symptoms that require treatment.

With current therapy, curing patients with multiple myeloma is uncommon; recent advances incorporating new precision medicines, immunotherapy, stem cell transplantation, and maintenance therapy however have prolonged survival by several years. The only potentially curative treatment for multiple myeloma remains high-dose therapy followed by a stem cell transplant using donor cells (allogeneic stem cell transplant). This treatment, however, is associated with significant side effects and is currently most only for younger patients or those who have failed other therapies.

There are several effective chemotherapy drugs increasingly combined with newer precision medicines and immunotherapy used as standard-dose induction treatment of patients with multiple myeloma. The main goal of initial therapy of multiple myeloma is to produce a complete or near complete disappearance of myeloma cells in the body. A majority of patients can expect to achieve this goal with current therapies.1

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About this Treatment Information

The following treatment overview summarizes the standard of care and recent advances in precision medicine treatment for stage II-III multiple myeloma. Optimal cancer treatment incorporates ongoing advances in precision medicine with chemotherapy, high-dose therapy and stem cell transplant, and maintenance therapy. Participation in a clinical trial utilizing new, innovative therapies may provide the most promising treatment. Learn more  Strategies to Improve Treatment.

Tip-Understanding Stem Cell Transplants

Planning Treatment for Multiple Myeloma

Before beginning treatment for multiple myeloma your physician may discuss with you the option of undergoing high-dose chemotherapy with an autologous stem cell transplant (ASCT), which utilizes a patient’s own stem cells. Most clinical trials conducted over the past two decades have shown that patients who undergo ASCT after they have achieved a remission with conventional chemotherapy experience improved outcomes.2

It is important to consider the possibility of a future ASCT at the time of diagnosis because stem cells have to be collected and frozen early in the disease course even if the initial treatment plan involves ASCT for treatment after a myeloma recurrence.

The other reason it is important to have this discussion is that opting to plan for an ASCT determines which chemotherapy drugs will make up the initial treatment. A type of chemotherapy drug called an alkylating agent such as Alkeran® (melphalan) damages stem cells making collection difficult or impossible. Thus, patients who elect to have stem cells collected and stored are frequently treated with induction regimens that do not include alkylating agents. Patients who elect not to receive a stem cell transplant, or who are not candidates for stem cell transplantation because of advanced age or poor health, are often treated with an Alkeran® -based regimen.

Induction Therapy & Chemotherapy
High Dose Chemotherapy and Stem Cell Transplant
Managing Complications & Side Effects of Myeloma
Strategies to Improve Treatment